Energy Characteristics of Electric Drive of Oscillatory Motion at the Shock-Free Start

The peculiarity of operation of oscillatory electric drive with doubly-fed motor at realization of algorithm of shock-free start was considered. The method of evaluating of energy parameters of such motors operating at the resonance mode with учетом of quantitative and qualitative components of the process of energy conversion by an electric motor (doubly-fed motor) is proposed. The calculation of energy characteristics of electric drive of this type was made, the results of calculation show an increase of energy efficiency (an average, generalized efficiency coefficient [eta]E increased by 10 %), which confirms the practical significance of the research object

The EROP-Moscow oligopeptide database

Natural oligopeptides may regulate nearly all vital processes. To date, the chemical structures of nearly 6000 oligopeptides have been identified from >1000 organisms representing all the biological kingdoms. We have compiled the known physical, chemical and biological properties of these oligopeptides—whether synthesized on ribosomes or by non-ribosomal enzymes—and have constructed an internet-accessible database, EROP-Moscow (Endogenous Regulatory OligoPeptides), which resides at . This database enables users to perform rapid searches via many key features of the oligopeptides, and to carry out statistical analysis of all the available information. The database lists only those oligopeptides whose chemical structures have been completely determined (directly or by translation from nucleotide sequences). It provides extensive links with the Swiss-Prot-TrEMBL peptide-protein database, as well as with the PubMed biomedical bibliographic database. EROP-Moscow also contains data on many oligopeptides that are absent from other convenient databases, and is designed for extended use in classifying new natural oligopeptides and for production of novel peptide pharmaceuticals

Use of Creeping Speed Mode in Discrete Control and Measuring Equipment with Digital-Program Control

The creeping speed mode is studied with calculation of the resultant vector of the flux linkage [psi]0 of the double-fed machine. It is shown that use of the double-fed machine as the actuating motor in the creeping speed mode increases the working off accuracy of the motion law. A mathematical model of the double-fed machine to study various modes of the CNC machine including the creeping speed mode is developed. The method to estimate the load parameters of the double-fed machine is presented. Practical implication of the study is confirmed by the results obtained in the evaluation of the influence of load parameters on the dynamic indicators of actuating electromotor

Special Modes of AC Drives Operation in the Mining Industry

This paper presents research of special modes of AC drives operation. The possibility of obtaining of vibrational and vibrational-rotational modes of the AC drives on the basis of multipurpose polyharmonic mode of actuating motor operation is shown. Multipurpose electric motor with improved power characteristics (double-fed machine) has been proposed as the actuating motor of the electroactivator of the coal grizzley. The formation algorithm of polyharmonic operation mode of the double-fed machine is developed. This algorithm allows studying different types of special modes of actuating motor. Research results of dynamic parameters of a universal electric motor of the electroactivator of the coal grizzley are presented. The practical significance of the study of using of double-fed machine in the primary coal processing is shown

Competence In Time As A Professional Activity Effectiveness Factor

The article shows that time competence is an important component of professional competence. The main factor of psychological time is the personal organization of life time, and it manifests itself in reflecting the objective time and dynamic characteristics of the psyche, and in the ability of the psyche to regulate and to personalize time. The study of time in the professional activity context contributes to better understanding of some reasons for low productivity of specialists, and also it provides an information base for the development of measures to optimize working hours. The article shows that young specialists have insufficient level of time competence, but they have good potential for its further development. The main factors were identified on the base and they contribute to the irrational time distribution. Some factors such as personal organization of time and procrastination affect time competence in the short term, but life satisfaction and holistic perception of time affect in the long term. A correlation has been determined on its base between irrational time usage and procrastination level. Timely identified low level of time competence for students and young specialists allows timely conduct a behavior correction aimed at optimizing working and personal time. It contributes to less professional burnout, prevention of depression, support for a high level of professional activity for several decades

Competence In Time As A Professional Activity Effectiveness Factor

The article shows that time competence is an important component of professional competence. The main factor of psychological time is the personal organization of life time, and it manifests itself in reflecting the objective time and dynamic characteristics of the psyche, and in the ability of the psyche to regulate and to personalize time. The study of time in the professional activity context contributes to better understanding of some reasons for low productivity of specialists, and also it provides an information base for the development of measures to optimize working hours. The article shows that young specialists have insufficient level of time competence, but they have good potential for its further development. The main factors were identified on the base and they contribute to the irrational time distribution. Some factors such as personal organization of time and procrastination affect time competence in the short term, but life satisfaction and holistic perception of time affect in the long term. A correlation has been determined on its base between irrational time usage and procrastination level. Timely identified low level of time competence for students and young specialists allows timely conduct a behavior correction aimed at optimizing working and personal time. It contributes to less professional burnout, prevention of depression, support for a high level of professional activity for several decades

Study of analgesic and myotropic spasmolytic activity of alkylcarb

The work is devoted to the search for new biologically active substances in a series of alkylamides of dihydroquinoline-3-carboxylic acid. Analgesic properties of 30 newly synthesized substances were studied, which made it possible to identify the leader compound (provisional name alkylcarb) and recommend its effectiveness for further research as an antispasmodic agent for pain relief. It has been established experimentally, that the substance alkylcarb exhibits concentration-dependent vasodilatory properties in vitro on segments of the thoracic aorta of rats. The data, obtained in the work, justify the prospect of using the leader substance as a new analgesic and antispasmodic drug. The research expands and deepens knowledge about the pharmacological properties of alkylamide derivatives of dihydroquinoline-3-carboxylic acid. The aim of the work was to conduct screening studies to establish the analgesic activity of a newly synthesized series of chemical compounds among alkylamides of dihydroquinoline-3-carboxylic acid and to study the myotropic spasmolytic activity of the leader substance. Materials and methods. Analgesic properties of alkylamides of dihydroquinoline-3-carboxylic acid were studied on outbred white mice in the "acetic acid convulsions" test. During the experiment, the animals were treated in accordance with the International Principles of the European Convention for the Protection of Vertebrate Animals Used for Experiments and Other Scientific Purposes (Strasbourg, March 18, 1986). The studied substances were administered intragastrically to experimental animals at a dose of 10 mg/kg in the form of a finely dispersed aqueous suspension, stabilized with Tween-80. Voltaren at a dose of 8 mg/kg, recommended for preclinical studies, and analgin at a dose of 50 mg/kg were chosen as reference drugs. The studies of the contractile activity of smooth muscle vessels were carried out on segments of the thoracic aorta of rats of both sexes weighing 180-200 g. The studies of dilator reactions were carried out against the background of preliminary contraction with phenylephrine at a concentration of 10-6 mol/l. The antispasmodic efficiency of the new compound was determined in comparison with the classic antispasmodic drotaverine. The statistical processing of the results was carried out using the package of statistical analysis of electronic spreadsheets Exel, with the help of the program "Statgraphics Plus v. 3.0.” and the standard package of statistical programs "Statistica, V. 6.0". We used the Student's test, a non-parametric analog of univariate variance analysis - the Kruskal-Wallis test, and the Mann-Whitney test. Differences were considered statistically significant at p<0.05. Results. The study of the analgesic activity of substances АO1-АO30 in the "acetic acid convulsion" test in mice showed that a compound АO26 (provisional name alkylcarb) has the most pronounced analgesic activity when administered intragastrically. In the "acetic acid convulsion" test, alkylcarb (10 mg/kg, per os) probably reduces the number of convulsions, caused by acetic acid. The level of activity of this compound is comparable to the activity of diclofenac (8 mg/kg, per os) and exceeds analgin (50 mg/kg, per os). The substance alkylcarb relieved vasospasm at the level of the comparison drug drotaverine in in vitro experiments on a model of an isolated fragment of the thoracic aorta of rats against the background of previous constriction with phenylephrine. Conclusion. Today, the search for new highly effective non-opioid analgesics is an urgent problem of modern pharmacology, since painkillers used in clinical practice do not meet the requirements of efficiency and safety. In this regard, in recent years, scientists of the National Pharmaceutical University have been intensively searching for new, highly effective substances with antinociceptive, anti-inflammatory and antipyretic effects among alkylamides of dihydroquinoline-3-carboxylic acid

Mosaic Structure as the Main Feature of Mycobacterium bovis BCG Genomes

Background: The genome stability of attenuated live BCG vaccine preventing the acute forms of childhood tuberculosis is an important aspect of vaccine production. The purpose of our study was a whole genome comparative analysis of BCG sub-strains and identification of potential triggers of sub-strains’ transition

Improving the heat resistance of polymer electrical insulation systems for the modernization of induction motors

Ensuring high power, efficiency and reliability of induction motor operation while providing small weight–size parameters represents an up-to-date problem. One of the factors limiting the reduction of weight–sizeparameters when increasing capacities of induction motors is the failure of the insulation system. Therefore, thereis a strong need for studying the issues of slot fill when designing an induction motor, taking into account anincrease in the heat resistance class of electrical insulation systems. The purpose of the present research is todevelop a polymeric electrical insulation system of increased heat resistance for the modernization of aninduction medium-capacity motor to reduce weight–size parameters and to evaluate the possible savings ofwinding material. The paper deals with an analysis on the stator–slot fill for the induction motor. Modernconductor and insulation materials were selected. The necessary calculations for a medium–power inductionmotor of different heat resistance classes were performed. The usage of the proposed electrical insulation systemwas substantiated. The analysis shows the possibility of increasing the heat resistance of the polymer electricalinsulation systems to save winding material for induction motors without reducing the specified quality level

The impact of lifestyle factors on age-related differences in hair trace element content in pregnant women in the third trimester

BACKGROUND: Trace elements play a significant role in the regulation of human reproduction, while advanced age may have a significant impact on trace element metabolism. The objective of the present study was to assess the impact of lifestyle factors on age-related differences in hair trace element content in pregnant women in the third trimester. METHODS: A total of 124 pregnant women aged 20&ndash;29 (n = 72) and 30&ndash;39 (n = 52) were ex- amined. Scalp hair trace element content was assessed using inductively coupled plasma mass spectrometry at NexION 300D (Perkin Elmer, USA) after microwave digestion. RESULTS: The results showed that the elder pregnant women had 36% (p = 0.009), 14% (p = 0.045), and 45% (p = 0.044) lower hair Zn, V, and Cd content, and 16% (p = 0.044) higher hair B levels &ndash; in comparison to the respective younger group values. Multiple regression analysis demonstrated that the age of the women had a significant influence on hair V and Zn levels. B content was also significantly influenced by age at first intercourse, smoking status, and specific dietary habits. None of the lifestyle factors were associated with hair Cd content in pregnant women. Hair V levels were also affected by following a special diet. Interestingly, alcohol intake did not have a significant impact on hair trace element content. CONCLUSIONS: These data indicate that lifestyle factors have a significant influence on age-related changes in hair trace elements during pregnancy that may impact the outcome of pregnancy